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I just looked this up, but who knows if it's exactly But what it tells you is it does very little other than determining what the gender is.

And the way it determines that, it does have one gene on it called the SRY gene. You don't have to know that. SRY, that plays a role in the development of testes or the male sexual organ.

So if you have this around, this gene right here can start coding for things that will eventually lead to the development of the testicles.

And if you don't have that around, that won't happen, so you'll end up with a female. And I'm making gross oversimplifications here.

But everything I've dealt with so far, OK, this clearly plays a role in determining sex. But you do have other traits on these genes.

And the famous cases all deal with specific disorders. So, for example, color blindness. The genes, or the mutations I should say. So the mutations that cause color blindness.

Red-green color blindness, which I did in green, which is maybe a little bit inappropriate. Color blindness and also hemophilia.

This is an inability of your blood to clot. Actually, there's several types of hemophilia. But hemophilia is an inability for your blood to clot properly.

And both of these are mutations on the X chromosome. And they're recessive mutations. So what does that mean? It means both of your X chromosomes have to have-- let's take the case for hemophilia-- both of your X chromosomes have to have the hemophilia mutation in order for you to show the phenotype of having hemophilia.

So, for example, if there's a woman, and let's say this is her genotype. She has one regular X chromosome and then she has one X chromosome that has the-- I'll put a little superscript there for hemophilia-- she has the hemophilia mutation.

She's just going to be a carrier. Her phenotype right here is going to be no hemophilia. She'll have no problem clotting her blood.

The only way that a woman could be a hemophiliac is if she gets two versions of this, because this is a recessive mutation.

Now this individual will have hemophilia. Now men, they only have one X chromosome. So for a man to exhibit hemophilia, to have this phenotype, he just needs it only on the one X chromosome he has.

And then the other one's a Y chromosome. So this man will have hemophilia. So a natural question should be arising is, hey, you know this guy-- let's just say that this is a relatively infrequent mutation that arises on an X chromosome-- the question is who's more likely to have hemophilia?

A male or a female? All else equal, who's more likely to have it? Well if this is a relatively infrequent allele, a female, in order to display it, has to get two versions of it.

So let's say that the frequency of it-- and I looked it up before this video-- roughly they say between 1 in 5, to 10, men exhibit hemophilia.

So let's say that the allele frequency of this is 1 in 7,, the frequency of Xh, the hemophilia version of the X chromosome.

And that's why 1 in 7, men display it, because it's completely determined whether-- there's a 1 in 7, chance that this X chromosome they get is the hemophilia version.

Who cares what the Y chromosome they get is, cause that essentially doesn't code at all for the blood clotting factors and all of the things that drive hemophilia.

Now, for a woman to get hemophilia, what has to happen? She has to have two X chromosomes with the mutation. Well the probability of each of them having the mutation is 1 in 7, So the probability of her having hemophilia is 1 in 7, times 1 in 7,, or that's 1 in what, 49 million.

So as you can imagine, the incidence of hemophilia in women is much lower than the incidence of hemophilia in men.

And in general for any sex-linked trait, if it's recessive, if it's a recessive sex-linked trait, which means men, if they have it, they're going to show it, because they don't have another X chromosome to dominate it.

Or for women to show it, she has to have both versions of it. The incidence in men is going to be, so let's say that m is the incidence in men.

I'm spelling badly. Then the incidence in women will be what? You could view this as the allele frequency of that mutation on the X chromosome.

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Well, your mom's always going to be donating an X chromosome. And then your dad is going to donate either the X or the Y.

So in this case, it'll be the Y chromosome. So these would be female, and those would be male. And it works out nicely that half are female and half are male.

But a very interesting and somewhat ironic fact might pop out at you when you see this. Who determines whether their offspring are male or female?

Is it the mom or the dad? Well, the mom always donates an X chromosome, so in no way does what the haploid genetic makeup of the mom's eggs, of the gamete from the female, in no way does that determine the gender of the offspring.

It's all determined by whether-- let me just draw a bunch of-- dad's got a lot of sperm, and they're all racing towards the egg.

And some of them have an X chromosome in them and some of them have a Y chromosome in them. And obviously they have others.

And obviously if this guy up here wins the race. Or maybe I should say this girl. If she wins the race, then the fertilized egg will develop into a female.

If this sperm wins the race, then the fertilized egg will develop into a male. And the reason why I said it's ironic is throughout history, and probably the most famous example of this is Henry the VIII.

I mean it's not just the case with kings. It's probably true, because most of our civilization is male dominated, that you've had these men who are obsessed with producing a male heir to kind of take over the family name.

And they become very disappointed and they tend to blame their wives when the wives keep producing females, but it's all their fault. I'm not an expert here, but the general notion is that he became upset with her that she wasn't producing a male heir.

And then he found a reason to get her essentially decapitated, even though it was all his fault. He was maybe producing a lot more sperm that looked like that than was looking like this.

He eventually does produce a male heir so he was-- and if we assume that it was his child-- then obviously he was producing some of these, but for the most part, it was all Henry the VIII's fault.

So that's why I say there's a little bit of irony here. Is that the people doing the blame are the people to blame for the lack of a male heir.

Now one question that might immediately pop up in your head is, Sal, is everything on these chromosomes related to just our sex-determining traits or are there other stuff on them?

So let me draw some chromosomes. So let's say that's an X chromosome and this is a Y chromosome. Now the X chromosome, it does code for a lot more things, although it is kind of famously gene poor.

It codes for on the order of 1, genes. And the Y chromosome, it's the most gene poor of all the chromosomes.

It only codes for on the order of 78 genes. I just looked this up, but who knows if it's exactly But what it tells you is it does very little other than determining what the gender is.

And the way it determines that, it does have one gene on it called the SRY gene. You don't have to know that. SRY, that plays a role in the development of testes or the male sexual organ.

So if you have this around, this gene right here can start coding for things that will eventually lead to the development of the testicles. And if you don't have that around, that won't happen, so you'll end up with a female.

And I'm making gross oversimplifications here. But everything I've dealt with so far, OK, this clearly plays a role in determining sex.

But you do have other traits on these genes. And the famous cases all deal with specific disorders. So, for example, color blindness.

The genes, or the mutations I should say. So the mutations that cause color blindness. Red-green color blindness, which I did in green, which is maybe a little bit inappropriate.

Color blindness and also hemophilia. This is an inability of your blood to clot. Actually, there's several types of hemophilia. But hemophilia is an inability for your blood to clot properly.

And both of these are mutations on the X chromosome. And they're recessive mutations. Quite possibly the most disturbing film you'll ever see: urination, defecation, semen, blood, gore, animal cruelty NC min Horror, Mystery, Thriller.

An aging porn star agrees to participate in an "art film" in order to make a clean break from the business, only to discover that he has been drafted into making a pedophilia and necrophilia themed snuff film.

Votes: 56, Unrated 76 min Drama, Romance. In a squalid apartment in Berlin, an unconventional director strives to capture unadulterated feelings, raw passion and undiluted sex for an experimental film project about love.

The film shows offensively and intensively the lawless addiction of living - but what are we actually seeking for in life?

A young single mother drops her son of at the bus stop to visit his dad in Paris. After being late for work, she almost gets fired. At the end of her duties she gets into a tricky situation which she handles, with the advice her colleague gave her.

Votes: 2, Unrated min Drama. In the face of her family life falling to pieces, a social media-obsessed teenage girl falls into a hedonistic world of sex, drugs and abuse.

Votes: 6, Brilliant but controversial film follows the day to day life of a 14 year old teen in an estate in Serbia as she tries hard to forget her father's illness with sex and partying.

A group of women in Morocco make a living as prostitutes in a culture that is very unforgiving toward women in that profession.

Unrated 85 min Drama. After Nihilistic rapper Gandu steals from his mother's lover, he embarks on a drug-fueled rampage with a rickshaw puller in this abstract film.

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An erotic tale of a group of 20 somethings in a seaside town Elles Unrated 99 min Drama 5.

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